{"id":1537,"date":"2022-06-10T15:15:04","date_gmt":"2022-06-10T18:15:04","guid":{"rendered":"https:\/\/new-website.wecann.academy\/2022\/06\/10\/understand-the-entourage-effect-and-why-the-complete-plant-is-better-than-its-isolated-parts\/"},"modified":"2025-10-19T23:31:09","modified_gmt":"2025-10-20T02:31:09","slug":"understand-the-entourage-effect-and-why-the-complete-plant-is-better-than-its-isolated-parts","status":"publish","type":"post","link":"https:\/\/wecann.academy\/en\/understand-the-entourage-effect-and-why-the-complete-plant-is-better-than-its-isolated-parts\/","title":{"rendered":"Understand the entourage effect and why the complete plant is better than its isolated parts"},"content":{"rendered":"

According to Aristotle, \u201cthe totality is more than the sum of its parts.\u201d<\/strong>The Greek philosopher\u2019s statement may well apply to the medicinal properties of plants, especially Cannabis, with regard to the concept of the entourage effect.\u00a0<\/p>\n

And in fact, studies show that complete plant extracts <\/strong>prove to be more effective in health treatments than the use of isolated or synthetic cannabinoids.\u00a0<\/p>\n

But, after all, what is the entourage effect?<\/h2>\n

Entourage effect is the synergistic relationship between all chemical compounds present in Cannabis.<\/strong>That is, it occurs when the complete extract of the plant is used (including all cannabinoids, terpenes, flavonoids, among other substances) and not just isolated parts.\u00a0<\/p>\n

A clearly observed benefit is in the interaction between the two main phytocannabinoids THC and CBD.<\/strong>The combination of CBD and THC helps to reduce potential THC side effects, while the combination of THC and CBD helps to reduce the average dose needed to treat with CBD.\u00a0<\/p>\n

> Read more at <\/strong><\/span><\/span>What are Cannabis-based medicines and what are they for?<\/strong><\/span><\/span><\/a><\/span><\/p>\n

In the entourage effect, the molecules not only modulate the potential adverse effects of some component, but also potentiate the therapeutic effects.<\/strong>.\u00a0<\/p>\n

This <\/span><\/span>study<\/span><\/span><\/a> brilliantly compared groups of patients with severe and refractory epilepsy who used CBD alone to other groups with the same clinical picture, but who used the complete plant extract predominant in CBD.\u00a0<\/p>\n

The results showed that a dose of at least 4 times higher of CBD alone is necessary, when compared to the complete extract of the plant, to reach the same therapeutic effects.<\/strong>.\u00a0<\/p>\n

Furthermore, the incidence of adverse effects in the groups that treated with CBD alone was significantly higher than in the groups that treated with the whole plant extract.<\/p>\n

> Check out the full article <\/strong><\/span><\/span>Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis<\/strong><\/span><\/span><\/a><\/span><\/p>\n

This <\/span><\/span>study<\/span><\/span><\/a> published in 2018, on the other hand, brings another relevant differential in the prescription of full spectrum products (made with the complete extract of the plant) and the entourage effect: it demonstrates the increase in antineoplastic responses in<\/b> breast cancer <\/strong><\/span><\/span><\/a>tumor cells from the administration of extracts from the complete plant with a predominance of THC compared to THC alone. <\/span><\/span><\/p>\n

> Read at <\/strong><\/span><\/span>Appraising the \u201centourage effect\u201d: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer<\/strong><\/span><\/span><\/a><\/span><\/p>\n

Entourage effect and Endocannabinoid System<\/h2>\n

The <\/span><\/span>Endocannabinoid System<\/span><\/span><\/a> (ECS) is a vital regulatory system present in humans and all vertebrate animals. This system is involved in virtually all of our physiological and pathological processes. It is made up of receptors and ligands and enzymes that act as signalers between cells. The entourage effect is directly related to<\/span><\/span> <\/u>SE<\/span><\/span><\/a>since it is responsible for creating and decomposing cannabinoid substances in our body.<\/p>\n

According to <\/span><\/span>Dr. Ethan Russo<\/span><\/span><\/a>neurologist, international reference in research in the field of psychopharmacology and medicinal cannabis, there is an \u201cherbal synergy\u201d among the less studied compounds of the Cannabis plant, similar to those found in the endocannabinoid system.<\/strong><\/p>\n

> Read the article <\/strong><\/span><\/span>Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects<\/strong><\/span><\/span><\/a><\/span><\/p>\n

Returning to reflecting on the totality suggested by Aristotle, we can also reach the concept of <\/span><\/span>emergence<\/span><\/span><\/a>which is described in science as the formation of complex standards from several simple interactions. <\/strong>Some of its examples are the mind itself (neurons alone do not generate all the complexity of the human mind) and complex organisms (which need different cells to reach their potential).\u00a0<\/p>\n

Likewise, the various chemical compounds found in Cannabis, when used together, have effects that would not be achieved to their full potential if they were used only individually.\u00a0<\/p>\n

Quer saber mais sobre sistema endocanabinoide, utiliza\u00e7\u00e3o medicinal de derivados canabinoides e produtos full spectrum<\/em>? Acesse o nosso E-book e entenda como interagem o sistema endocanabinoide, seus receptores e os fitocanabinoides. <\/span><\/span>\u00a0<\/p>\n

\"\"<\/a><\/p>\n

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References<\/strong><\/p>\n

BILES, Mary. <\/span><\/span>What is the entourage effect?<\/span><\/span><\/a> The Cannigma, 2019. Dispon\u00edvel em <\/span><\/span><<\/span><\/span>https:\/\/cannigma.com\/treatment\/what-is-the-entourage-effect\/<\/span><\/span><\/a>><\/span><\/span>. Acesso: 07 de junho de 2021.\u00a0<\/p>\n

Blasco-Benito S, Seijo-Vila M, Caro-Villalobos M, Tundidor I, Andradas C, Garc\u00eda-Taboada E, Wade J, Smith S, Guzm\u00e1n M, P\u00e9rez-G\u00f3mez E, Gordon M, S\u00e1nchez C. <\/span><\/span>Appraising the \u201centourage effect\u201d: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer<\/span><\/span><\/a>. Biochem Pharmacol. 2018.\u00a0<\/p>\n

LESTIENNE, R\u00e9my.<\/span><\/span> Emerg\u00eancia, um novo paradigma indispens\u00e1vel para as ci\u00eancias e a filosofia?<\/span><\/span><\/a>. Cienc. Cult.,\u00a0 S\u00e3o Paulo ,\u00a0 v. 65, n. 4, p. 20-21, 2013.\u00a0<\/p>\n

PAMPLONA, Fabricio A. <\/span><\/span>Quais s\u00e3o e pra que servem os medicamentos \u00e0 base de Cannabis?<\/span><\/span><\/a> Revista da Biologia, [s.l.], v. 13, n. 1, p.28-35, dez. 2014. Revista da Biologia, Reitoria da Universidade de S\u00e3o Paulo.\u00a0<\/p>\n

Pamplona FA, da Silva LR, Coan AC. <\/span><\/span>Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis<\/span><\/span><\/a>. Front Neurol. 2018 Sep 12;9:759. doi: 10.3389\/fneur.2018.00759. Erratum in: Front Neurol. 2019 Jan 10;9:1050. PMID: 30258398; PMCID: PMC6143706.<\/p>\n

Russo, Ethan B. <\/span><\/span>Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects<\/span><\/span><\/a>. British journal of pharmacology vol. 163,7 (2011): 1344-64. doi:10.1111\/j.1476-5381.2011.01238.x<\/p>\n

\u00a0<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

According to Aristotle, \u201cthe totality is more than the sum of its parts.\u201dThe Greek philosopher\u2019s statement may well apply to the medicinal properties of plants, especially Cannabis, with regard to the concept of the entourage effect.\u00a0 And in fact, studies show that complete plant extracts prove to be more effective in health treatments than the […]<\/p>\n","protected":false},"author":2,"featured_media":1375,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1537","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sem-categoria"],"acf":[],"_links":{"self":[{"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/posts\/1537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/comments?post=1537"}],"version-history":[{"count":4,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/posts\/1537\/revisions"}],"predecessor-version":[{"id":3547,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/posts\/1537\/revisions\/3547"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/media\/1375"}],"wp:attachment":[{"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/media?parent=1537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/categories?post=1537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wecann.academy\/en\/wp-json\/wp\/v2\/tags?post=1537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}